TY - JOUR ID - 5474 TI - Electromechanical modeling and simulation of the physiological state of human gastric wall smooth muscle cells JO - Computational Sciences and Engineering JA - CSE LA - en SN - AU - Taghadosi, Hossein AU - Tabatabai Ghomsheh, Farhad AU - Farajidavar, Aydin AU - Khazaee, Faezeh AU - Hoseinpour, Fatemeh AU - Beshkooh, Zahra AD - Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. AD - Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. AD - Department of Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, New York, USA. AD - Department of Occupational Therapy, Semnan University of Medical Science, Semnan, Iran. Y1 - 2022 PY - 2022 VL - 2 IS - 1 SP - 9 EP - 19 KW - Electromechanical Modeling KW - Simulation KW - Gastric Wall KW - Slow Wave KW - Smooth Muscle Cell KW - Contraction DO - 10.22124/cse.2022.21929.1026 N2 - Electromechanical and regular contractions of the smooth muscles of the gastric wall are responsible for grinding, mixing, and propulsion food into the intestines. Lack of proper functioning in contracting the smooth muscle causes digestive disorders. This study aimed to present an electromechanical model for the contraction of smooth muscles of the human gastric wall in the physiological state. In this model, the electromechanical contraction of the smooth muscles is due to the distribution of the electrophysiological slow wave (Due to ionic interaction of cells with extracellular environment and adjacent cells) over 240 cells and 548 links. The results showed that the contraction started at the beginning of the gastric wall and gradually transferred to the end of the wall (pylorus). Also, it was found that the maximum contraction of about 34.7% occurs at the end of the model and near the pyloric sphincter. Finally, the behavior of tissues can be simulated non-invasively using the modeling and their function can be examined under physiological and pathological conditions. UR - https://cse.guilan.ac.ir/article_5474.html L1 - https://cse.guilan.ac.ir/article_5474_cf51163f70582d5df7776905b2b5d436.pdf ER -