Document Type : Original Article
Authors
- Reza Zarei 1
- Seyyedeh Sahra Mirmasoudi 2
- Alireza Feizkhah 3
- Zahra Pourmohammadi Bejarpasi 4
- Mohsen Shahrousvand 5
1 Department of Statistics, Faculty of Mathematical Sciences, University of Guilan, Rasht, Iran.
2 Burn and Regenerative Medicine Research center, Guilan University of Medical Sciences, Rasht
3 Department of Medical Physics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
4 Burn and Regenerative Medicine Research center, Guilan University of Medical Sciences, Rasht, Iran
5 Caspian Faculty of Engineering, College of Engineering, University of Tehran, Tehran, Iran
Abstract
This study focuses on optimizing process of the blood coagulation powder composition with response surface methodology. For this purpose, optimizing the synthesis conditions of powder composition, the response surface methodology (RSM) was used by Box-Behnken design (BBD). The variables of this method were sodium alginate (A) and zinc oxide nanoparticles (B), prepared in combination with a fixed percentage of shell powder and measured for different reactions. results showed that according to the response surface methodology, which is the most optimal case, to introduce this method as a suitable suggestion for this kind of problem in the applications of vascular surgeries, burns, etc., and direct to future pre-clinic and clinical studies.
Keywords
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